? Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides to support projects in multiple disease areas.
? Optimization and scale up of processing methods
? Supports continuous improvement initiatives by identifying areas needing improvement, recommending strategies for improvement, and helping to implementing those strategies once approved
? Ability to operate and maintain lab instruments such as AKTA synthesizers, purifiers and HPLC and LC-MS
? Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
? Familiarity with pre-clinical drug development and IND-enabling phase of therapeutic programs
? Collaborative team player who is also proficient at leading projects and motivating teams
? Capacity to be highly productive in a fluid and fast-paced work environment
? PhD in Organic Chemistry or related. Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques. Candidates with demonstrable hands-on nucleotide drug discovery and pre-clinical development experience in pharmaceutical/biotech industry is a plus.
? Experience in scale up and technology transfer of processing
? Experience with the AKTA line of synthesizers
? Familiarity with analytical techniques and data interpretation HPLC, LC-MS, UV-Vis